The publications of the members of Est srl.
2023
Piano, Raffaelle De; Caccavo, Diego; Lamberti, Gaetano; Remaut, Katrien; Seynaeve, Hanne; Barba, Anna Angela
A New Productive Approach and Formulative Optimization for Curcumin Nanoliposomal Delivery Systems Journal Article
In: Pharmaceutics, vol. 15, iss. 3, no. 959, 2023, ISSN: 19994923.
Abstract | Links | BibTeX | Tags: anticancer, antioxidant activity, curcumin, nanoliposomes, nanotechnologies, nutraceuticals, simil-microfluidic technology
@article{Piano}2023,
title = {A New Productive Approach and Formulative Optimization for Curcumin Nanoliposomal Delivery Systems},
author = {Raffaelle {De Piano} and Diego Caccavo and Gaetano Lamberti and Katrien Remaut and Hanne Seynaeve and Anna Angela Barba},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85151381874&doi=10.3390%2fpharmaceutics15030959&partnerID=40&md5=fceef78253390aceb67f23b8ff583eb8},
doi = {10.3390/pharmaceutics15030959},
issn = {19994923},
year = {2023},
date = {2023-03-16},
urldate = {2023-03-16},
journal = {Pharmaceutics},
volume = {15},
number = {959},
issue = {3},
abstract = {The use of natural resources and the enhancing of technologies are outlining the strategies of modern scientific-technological research for sustainable health products manufacturing. In this context, the novel simil-microfluidic technology, a mild production methodology, is exploited to produce liposomal curcumin as potential powerful dosage system for cancer therapies and for nutraceutical purposes. Through simil-microfluidic technology, based on interdiffusion phenomena of a lipid-ethanol phase in an aqueous flow, massive productions of liposomes at nanometric scale can be obtained. In this work, studies on liposomal production with useful curcumin loads were performed. In particular, process issues (curcumin aggregations) were elucidated and formulation optimization for curcumin load was performed. The main achieved result has been the definition of operative conditions for nanoliposomal curcumin production with interesting loads and encapsulation efficiencies.},
keywords = {anticancer, antioxidant activity, curcumin, nanoliposomes, nanotechnologies, nutraceuticals, simil-microfluidic technology},
pubstate = {published},
tppubtype = {article}
}
The use of natural resources and the enhancing of technologies are outlining the strategies of modern scientific-technological research for sustainable health products manufacturing. In this context, the novel simil-microfluidic technology, a mild production methodology, is exploited to produce liposomal curcumin as potential powerful dosage system for cancer therapies and for nutraceutical purposes. Through simil-microfluidic technology, based on interdiffusion phenomena of a lipid-ethanol phase in an aqueous flow, massive productions of liposomes at nanometric scale can be obtained. In this work, studies on liposomal production with useful curcumin loads were performed. In particular, process issues (curcumin aggregations) were elucidated and formulation optimization for curcumin load was performed. The main achieved result has been the definition of operative conditions for nanoliposomal curcumin production with interesting loads and encapsulation efficiencies.