The publications of the members of Est srl.
2024
Caccavo, Diego; Lamberti, Gaetano; Barba, Anna Angela
Analysis and simulation of wet-granulation processes Journal Article
In: Journal of the Taiwan Institute of Chemical Engineers, vol. 159, iss. 105455, 2024.
Abstract | Links | BibTeX | Tags: Dynamic image analysis, Modeling, Particle size distribution, Population balance equation, Wet-granulation
@article{Caccavo2024,
title = {Analysis and simulation of wet-granulation processes},
author = {Diego Caccavo and Gaetano Lamberti and Anna Angela Barba},
url = {https://doi.org/10.1016/j.jtice.2024.105455},
doi = {10.1016/j.jtice.2024.105455},
year = {2024},
date = {2024-03-22},
urldate = {2024-03-22},
journal = {Journal of the Taiwan Institute of Chemical Engineers},
volume = {159},
issue = {105455},
abstract = {Size enlargement by wet-granulation is one of the most important unit operation in several industrial fields: pharmaceutics, food processing, animal nutrition, agronomics, and so on. A lot of techniques have been used in order to measure the particle size distributions (PSD) and a few different approaches are available to model the PSD evolution during the process, mainly based on population balance equations (PBE). However, difficulties in both the activities (reliable measurement and robust modeling) have hindered their diffusion in industrial practice, keeping the granulation closer to an art than to a science.Size enlargement by wet-granulation is one of the most important unit operation in several industrial fields: pharmaceutics, food processing, animal nutrition, agronomics, and so on. A lot of techniques have been used in order to measure the particle size distributions (PSD) and a few different approaches are available to model the PSD evolution during the process, mainly based on population balance equations (PBE). However, difficulties in both the activities (reliable measurement and robust modeling) have hindered their diffusion in industrial practice, keeping the granulation closer to an art than to a science.},
keywords = {Dynamic image analysis, Modeling, Particle size distribution, Population balance equation, Wet-granulation},
pubstate = {published},
tppubtype = {article}
}
Size enlargement by wet-granulation is one of the most important unit operation in several industrial fields: pharmaceutics, food processing, animal nutrition, agronomics, and so on. A lot of techniques have been used in order to measure the particle size distributions (PSD) and a few different approaches are available to model the PSD evolution during the process, mainly based on population balance equations (PBE). However, difficulties in both the activities (reliable measurement and robust modeling) have hindered their diffusion in industrial practice, keeping the granulation closer to an art than to a science.Size enlargement by wet-granulation is one of the most important unit operation in several industrial fields: pharmaceutics, food processing, animal nutrition, agronomics, and so on. A lot of techniques have been used in order to measure the particle size distributions (PSD) and a few different approaches are available to model the PSD evolution during the process, mainly based on population balance equations (PBE). However, difficulties in both the activities (reliable measurement and robust modeling) have hindered their diffusion in industrial practice, keeping the granulation closer to an art than to a science.
2023
Mancino, Raffaele; Caccavo, Diego; Barba, Anna Angela; Lamberti, Gaetano; Biasin, Alice; Cortesi, Angelo; Grassi, Gabriele; Grassi, Mario; Abrami, Michela
Agarose Cryogels: Production Process Modeling and Structural Characterization Journal Article
In: Gels, vol. 9, iss. 9, no. 765, 2023, ISSN: 23102861.
Abstract | Links | BibTeX | Tags: agarose, cryogels, Equilibrium, Hydrogels, Modeling, rheology
@article{Mancino2023,
title = {Agarose Cryogels: Production Process Modeling and Structural Characterization },
author = {Raffaele Mancino and Diego Caccavo and Anna Angela Barba and Gaetano Lamberti and Alice Biasin and Angelo Cortesi and Gabriele Grassi and Mario Grassi and Michela Abrami},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172281028&doi=10.3390%2fgels9090765&partnerID=40&md5=7753d30977c1b97694c4ede138749d57},
doi = {10.3390/gels9090765},
issn = {23102861},
year = {2023},
date = {2023-09-20},
urldate = {2023-09-20},
journal = {Gels},
volume = {9},
number = {765},
issue = {9},
abstract = {A cryogel is a cross-linked polymer network with different properties that are determined by its manufacturing technique. The formation of a cryogel occurs at low temperatures and results in a porous structure whose pore size is affected by thermal conditions. The adjustable pore sizes of cryogels make them attractive for diverse applications. In this study, the influence of the external operational temperature, which affects the cooling and freezing rates, on the production of cryogels with 2% w/w agarose is investigated. Moreover, a mathematical model is developed to simulate the cryogel production process and provide an initial estimate of the pore size within the structure. The predictions of the model, supported by qualitative light microscopy images, demonstrate that cryogels produced at higher process temperatures exhibit larger pore sizes. Moreover, the existence of pore size distribution within the gel structure is confirmed. Finally, stress relaxation tests, coupled with an image analysis, validates that cryogels produced at lower temperatures possess a higher stiffness and slower water release rates.},
keywords = {agarose, cryogels, Equilibrium, Hydrogels, Modeling, rheology},
pubstate = {published},
tppubtype = {article}
}
A cryogel is a cross-linked polymer network with different properties that are determined by its manufacturing technique. The formation of a cryogel occurs at low temperatures and results in a porous structure whose pore size is affected by thermal conditions. The adjustable pore sizes of cryogels make them attractive for diverse applications. In this study, the influence of the external operational temperature, which affects the cooling and freezing rates, on the production of cryogels with 2% w/w agarose is investigated. Moreover, a mathematical model is developed to simulate the cryogel production process and provide an initial estimate of the pore size within the structure. The predictions of the model, supported by qualitative light microscopy images, demonstrate that cryogels produced at higher process temperatures exhibit larger pore sizes. Moreover, the existence of pore size distribution within the gel structure is confirmed. Finally, stress relaxation tests, coupled with an image analysis, validates that cryogels produced at lower temperatures possess a higher stiffness and slower water release rates.
De Piano, Raffaella; Caccavo, Diego; Barba, Anna Angela; Lamberti, Gaetano
Polyelectrolyte hydrogels in biological systems: Modeling of swelling and deswelling behavior Journal Article
In: Chemical Engineering Science, vol. 279, 2023.
Abstract | Links | BibTeX | Tags: Equilibrium, Hydrogels, Modeling, nutraceuticals, Polyelectrolytes
@article{nokey,
title = {Polyelectrolyte hydrogels in biological systems: Modeling of swelling and deswelling behavior},
author = {{De Piano, Raffaella} and Diego Caccavo and Anna Angela Barba and Gaetano Lamberti},
doi = {https://doi.org/10.1016/j.ces.2023.118959},
year = {2023},
date = {2023-06-05},
urldate = {2023-06-05},
journal = {Chemical Engineering Science},
volume = {279},
abstract = {Polyelectrolyte hydrogels are a particular class of hydrogel whose behavior is connected to the variation of pH in the surrounding solution. Their behavior is influenced by the ionizable groups present on their chain. These groups could be acid or basic and polyelectrolytes could be anionic or cationic. To fully understand their behavior mathematical modeling has been widely used over many years. In this work a model based on a monophasic approach will be used to describe a general behavior of anionic hydrogels in a steady state condition at pH lower (or equal) to seven. Free swelling experiments and constrained swelling experiments have been simulated varying the parameters of the model to highlight the properties of the material. From a comparison with experimental data, it results that the proposed model can describe the general behavior of the system as described in the literature.},
keywords = {Equilibrium, Hydrogels, Modeling, nutraceuticals, Polyelectrolytes},
pubstate = {published},
tppubtype = {article}
}
Polyelectrolyte hydrogels are a particular class of hydrogel whose behavior is connected to the variation of pH in the surrounding solution. Their behavior is influenced by the ionizable groups present on their chain. These groups could be acid or basic and polyelectrolytes could be anionic or cationic. To fully understand their behavior mathematical modeling has been widely used over many years. In this work a model based on a monophasic approach will be used to describe a general behavior of anionic hydrogels in a steady state condition at pH lower (or equal) to seven. Free swelling experiments and constrained swelling experiments have been simulated varying the parameters of the model to highlight the properties of the material. From a comparison with experimental data, it results that the proposed model can describe the general behavior of the system as described in the literature.